The Entourage Effect

Research and Development

The Entourage Effect


First described in 1998 by Israeli scien­tists Shimon Ben-Shabat and Raphael Mechoulam, the basic idea of the entourage effect is that cannabi­noids within the cannabis plant work together, or possess synergy, and affect the body in a mecha­nism similar to the body’s own endocannabi­noid system.

The entourage effect theory has been expanded in recent times to include the following:

  • Ability to affect multiple targets within the body
  • Ability to improve the absorp­tion of active ingredients
  • Ability to overcome bacte­rial defense mechanisms
  • Ability to minimize adverse side effects

Overall, the cannabi­noid system is prone to “entourage effect”, whether THC being poten­ti­ated by other cannabi­noids or by terpene compounds. Therapix’s leading entourage compound is PEA. Combining PEA with THC may stimu­late cannabi­noid recep­tors, inhibit metabolic degra­da­tion, and thus increase uptake of THC. The overall benefits of the PEA combi­na­tion are consid­ered to be an increase in efficiency of oral admin­is­tra­tion, enabling a decrease in dosage and lowering of side effects and adverse events.