The Entourage Effect
First described in 1998 by Israeli scientists Shimon Ben-Shabat and Raphael Mechoulam, the basic idea of the entourage effect is that cannabinoids within the cannabis plant work together, or possess synergy, and affect the body in a mechanism similar to the body’s own endocannabinoid system.
The entourage effect theory has been expanded in recent times to include the following:
- Ability to affect multiple targets within the body
- Ability to improve the absorption of active ingredients
- Ability to overcome bacterial defense mechanisms
- Ability to minimize adverse side effects
Overall, the cannabinoid system is prone to “entourage effect”, whether THC being potentiated by other cannabinoids or by terpene compounds. Therapix’s leading entourage compound is PEA. Combining PEA with THC may stimulate cannabinoid receptors, inhibit metabolic degradation, and thus increase uptake of THC. The overall benefits of the PEA combination are considered to be an increase in efficiency of oral administration, enabling a decrease in dosage and lowering of side effects and adverse events.